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My point was that heroin should be available for those who are in pain, not people who just want to get high. You don't have to inject heroin, just like it's totally possible to inject oxymorphone/roxycodone/etc. It's dangerous, but addicts don't give a shit; they just want to get high. The only reason fentanyl doesn't have as much potential for abuse is because it's extremely rare (a good thing) and most people overdose before they can develop a habit. Wilco's Jay Bennett died of a fentanyl overdose, which he was legally prescribed.
If cannabis was legal it could be prescribed in most cases of minor to moderate pain. I love taking painkillers, but I recognize that they cause a LOT of problems.
Most anti-depressants these days are SSRI's. Your argument also depends on someone abusing MDMA vs. taking it after your brain has recovered (supposed to be about a month or so). Anti-depressants, on the other hand, require you to take them every day and mess with your brain chemistry far worse than MDMA does.
I'm not trying to change your mind, but I'm just trying to state that the majority (doesn't mean ALL) illegal drugs have a stigma that usually doesn't have any basis in fact. If it does, chances are a pharmaceutical company sells a product that does far more harm.
Edit: As a fun fact, heroin's addictive properties go up exponentially when you inject it. Snorting it feels just like any other painkiller. I wasn't all that impressed with it, but I would never stick a needle in my arm. Same deal with cocaine.
I am largely against the use of antidepresents (despite my sheer facination with the chemistry of them). They cause more harm them good in the majority of cases, and I get pissed when I hear that someone is on an antidepressent. Again, because as you said they are taken often and get intergrated into the persons biochemistry, and alter it as well. That doesn't mean that people don't need them, but they are overperscribed, and wrongly given. mdma is still dangerous in my eyes because as I explained before, it causes damage, and has much higher risk factors.
The reason heroine is more addictive via injection is because it crosses the BBB very rapidly because it is a more lipophillic dervitive then straight morphine (heroin is a prodrug). As such, it's sole purpose is to get it into the body as rapidly as possible and is largely more damaging and dangerous because of this. There is a very small option (if at all) for thereputic use.