Two examples come to mind: Talos Principle (as you might have guessed from my avatar) and Disco Elysium.
The Talos Principle is, in the most simple terms, a cure for nihilism. As silly and self-contradictory that philosophy is (although what I'm talking about can be more accurately defined as a state of mind), it's still far too pervasive today, and this game has just the right antidote. This game is worth more than money, and it epitomizes the potential of video games that goes beyond satisfying gameplay or compelling story. There are so many fascinating analogies and parables throughout the game that explain the in-game world, which in turn bears much relevance to timeless concepts regarding human nature.
As for DE - what I truly love about this game is that it put me into a sort of trance. For a few days, it was like I adopted my super pumped conceptualization skill into real life, and saw completely mundane objects in a new light. It was a strange dream-like state, where a tree wasn't a tree, but a subterranean hand piercing the earth, reaching for something. I felt dissociated; and yet more lucid and alive than ever. It was immensely beautiful. I wish I could express how beautiful it was. I haven't been able to recreate that disposition of mind since, but I'm sure I wrote plenty of magniloquent ramblings in that frenzied affectation. Oh how I miss my disco glasses.
The way it handles character definition is unique and offers much depth. It has a bizarre balance where it offers you a humorous piece of dialog, only to reveal a deeply poignant moment of clarity about the state of the world a few minutes later. I've never experienced anything like that, and it's one of the few games that actually made me cry.
I'm only slightly exaggerating when I say both of these games deserve to be enshrined in a hall of greatest human creations.